Gambogic Acid Is a Tissue-Specific Proteasome Inhibitor In Vitro and In Vivo
Gambogic acid (GA) is a natural compound derived from Chinese herbs that has been approved by the Chinese Food and Drug Administration for clinical trials in cancer patients; however, its molecular targets have not been thoroughly studied.Here, we report that GA inhibits tumor proteasome activity, with potency comparable Toaster to bortezomib but m